http://www.ipcalculus.com 2010 © IPCalculus Services info@ipcalculus.com Patenting activity in RNA interference

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http://www.ipcalculus.com info@ipcalculus.com Overview 2010 © IPCalculus Services RNA interference (RNAi) is a system within living cells that helps to control which genes are active and how active they are in which double- stranded RNA (dsRNA) suppresses expression of a target protein by stimulating the specific degradation of the target mRNA. The RNAi pathway is found in many eukaryotes including animals & is initiated by the enzyme Dicer, which cleaves long double-stranded RNA (dsRNA) molecules into short fragments of ~20 nucleotides. The siRNA will be unwound into two ssRNA, namely the passenger strand and the guide strand. The passenger strand will be degraded, and the guide strand is incorporated into the RNA-induced silencing complex (RISC) which guides the RISC to the target mRNA. The catalytic components of RISC called "argonaute" carry out the degradation of target mRNA. RNA interference has an important role in defending cells against parasitic genes - viruses and transposons - but also in directing development as well as gene expression in general.

http://www.ipcalculus.com info@ipcalculus.com Technology classification As shown in the above mind map RNAi System is further categorized into Types of RNAs, Targeted gene/Protein, Delivery device, Delivery agent, Mode of administration, Function and Applications. This is the broad level classification of RNAi System. We at IPCalculus drill down each level class into niche technology areas. For example above mind map, we have categorize “Type of RNAs”, “Mode of administration”, “Function” and “Application” into the niche technology areas. Similarly we drill down other categories up to the last possible level. Our client-tailored report will help to identify competitors and track their IP activity even in to the niche segment of technology areas. Note: To access complete classification & comprehensive landscape report, please contact us at +1-619-618-0414 OR send your query on http://www.ipcalculus.com/contactus.php 2010 © IPCalculus Services

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http://www.ipcalculus.com info@ipcalculus.com 2010 © IPCalculus Services Issued and Published Patent Distribution by Application year

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http://www.ipcalculus.com info@ipcalculus.com About IPCalculus IPCalculus is an Intellectual Property research & analytical consulting firm based in India, providing customized services in the form of Patent landscape analysis, Patent portfolio analysis, Patent searches (Prior-art, Patentability/Novelty, Invalidation, Infringement, and Freedom to Operate), Patent alert and monitoring, Legal status updates, Trend analysis, Patent to Product mapping and Patent licensing. Our expertise lies in generating valuable IP intelligence by analyzing patent, non-patent, product, clinical trial, regulatory filing, premarket approval, recalls and other technical & competitive information. Our customized, interactive, dynamic & collaborative reporting system "IP Analytics Manager" integrate patent, non-patent, product, clinical trial, regulatory filing, premarket approval, recalls and other technical & competitive information. We provide consistent high quality IP research & analytical services in the field of medical devices, pharmaceutical, healthcare, biotechnology, life sciences, electronics, telecommunications, FMCG, chemistry, mechanical and many more. 2010 © IPCalculus Services

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