usmle step 1 Concept & Clues PART 2 Warning: graphic pictures intended for medical students only. The pictures are copied from yahoo images and various sites. Its for learning purpose only any problem please let me know and I will remove the pictures 1 conceptclues.blogspot.com 3/02/2009

What is another name for celebrex? Celecoxib 2 conceptclues.blogspot.com 3/02/2009

What type of inhibitor is celebrex COX 2 specific 3/02/2009 conceptclues.blogspot.com 3

What cox 2 specific drug can u give to patient with sulfa-allergy Vioxx (Rofecoxib) 3/02/2009 conceptclues.blogspot.com 4

What drugs inhibit dihydrofolate reductase Pyremethamine/sulfadiazine Trimethoprim/Sulfamethoxazole 3/02/2009 conceptclues.blogspot.com 5

What drugs cause pulmonary fibrosis Acronym: BBAT Bleomycin Bulsulfan Amiodarone Tocainide 3/02/2009 conceptclues.blogspot.com 6

What are the macrophage deficiency diseases Chediak-Higashi NADPH-Oxidase deficiency 3/02/2009 conceptclues.blogspot.com 7

What are the side effects of loops and thiazides H4 Hyperglycemia Hyperuricemia Hypovolemia Hypokalemia 3/02/2009 conceptclues.blogspot.com 8

What are the side effects of Loop Diuretics OH DANG Ototoxicity Hypokalemia Dehydration Allergy Nephritis (interstitial) Gout 3/02/2009 conceptclues.blogspot.com 9

What are the 3 pansystolic murmurs Mitral regurgitation Tricuspid regurgitation VSD = ventral septal defect 3/02/2009 conceptclues.blogspot.com 10

When is Mitral Regurgitation heard Decreases on inspiration and increases with expiration 3/02/2009 conceptclues.blogspot.com 11

When is Tricuspid Regurgitation heard Increased on inspiration 3/02/2009 conceptclues.blogspot.com 12

When is VSD heard Decrease on inspiration and increased on expiration 3/02/2009 conceptclues.blogspot.com 13

Macrophages(MФ) in various organs 3/02/2009 conceptclues.blogspot.com 14

MФ brain microglia 3/02/2009 conceptclues.blogspot.com 15

MФ lung Type I pneumocyte 3/02/2009 conceptclues.blogspot.com 16

MФ liver Kupffer cell 3/02/2009 conceptclues.blogspot.com 17

MФ spleen RES 3/02/2009 conceptclues.blogspot.com 18

MФ kidney Mesangial 3/02/2009 conceptclues.blogspot.com 19

MФ lymph nodes Dendritic 3/02/2009 conceptclues.blogspot.com 20

MФ skin Langerhans 3/02/2009 conceptclues.blogspot.com 21

MФ bone Osteoclasts 3/02/2009 conceptclues.blogspot.com 22

MФ connective tissue Histiocytes Diant cells Epithelioid cells 3/02/2009 conceptclues.blogspot.com 23

What are the 7 rashes of palms & soles TRiCKS2 TSS = toxic shock syndrome Rocky mountain spotted fever Coxsackie A (hand/foot & mouth dz) Kawasaki Syphillis Scarlet fever Staph scalded skin syndrome 3/02/2009 conceptclues.blogspot.com 24

What is seen in every restrictive lung disease Tachypnea Decrease pCO2 Decrease pO2 Increase pH 3/02/2009 conceptclues.blogspot.com 25

What are the different 2nd messenger systems cAMP cGMP IP3/DAG Ca:Calmodulin Ca+ Tyrosine Kinase NO = nitric oxide 3/02/2009 conceptclues.blogspot.com 26

Clue for cAMP It is 90% Sympathetic CRH (cortisol) Catabolic 3/02/2009 conceptclues.blogspot.com 27

Clue for cGMP Parasympathetic Anabolic 3/02/2009 conceptclues.blogspot.com 28

Clues for IP3/DAG Neurotransmitter GHRH All hypthalmic hormones EXCEPT: CORTISOL (CAMP) 3/02/2009 conceptclues.blogspot.com 29

IP3/DAG is used by what and for what Used by smooth muscle Used for contraction 3/02/2009 conceptclues.blogspot.com 30

Clue for Ca:Calmodulin Used by smooth muscle for contraction by distension 3/02/2009 conceptclues.blogspot.com 31

Clue for Ca+ Used by gastrin only 3/02/2009 conceptclues.blogspot.com 32

Clue for Tyrosine Kinase Used by insulins Used by ALL growth factors 3/02/2009 conceptclues.blogspot.com 33

Clue for NO=nitric oxide 3/02/2009 conceptclues.blogspot.com 34

What are the T & B cell deficiencies? 3/02/2009 conceptclues.blogspot.com 35

Clues for WAS 3/02/2009 conceptclues.blogspot.com 36

Clues for SCID 3/02/2009 conceptclues.blogspot.com 37

Clues for CVID 3/02/2009 conceptclues.blogspot.com 38

Clues for HIV 3/02/2009 conceptclues.blogspot.com 39

Clues for HTLV-1 3/02/2009 conceptclues.blogspot.com 40

What are the inhibitors of complex 1 of the ETC Amytal Rotenone 3/02/2009 conceptclues.blogspot.com 41

What are the inhibitors of complex 2of the ETC Malonate 3/02/2009 conceptclues.blogspot.com 42

What are the inhibitors of complex 3 of ETC Antimycin D 3/02/2009 conceptclues.blogspot.com 43

What are the inhibitors of Complex4 of the ETC CN (cyanide) CO (carbon monoxide) Chloramphenicol 3/02/2009 conceptclues.blogspot.com 44

What are the inhibitors of complex 5 of the ETC Oligomycin 3/02/2009 conceptclues.blogspot.com 45

What are the ETC chemical uncouplers DNP Free Fatty Acids Aspirin 3/02/2009 conceptclues.blogspot.com 46

What type of uncoupler is Aspirin Physical uncoupler 3/02/2009 conceptclues.blogspot.com 47

What are the 4 sources of Renal Acid 3/02/2009 conceptclues.blogspot.com 48

What is the one dose treatment for Hemophilus Ducreyi Azithromycin 1gram po Ceftriazone 250mg IM 3/02/2009 conceptclues.blogspot.com 49

What is one dose treatment for chlaymdia Azithromycin 1gram PO 3/02/2009 conceptclues.blogspot.com 50

What is the one dose treatment for candidiasis Ketoconazole 150mg 3/02/2009 conceptclues.blogspot.com 51

What is the one dose treatment for vaginal candidiasis Difluccan 1 pill 3/02/2009 conceptclues.blogspot.com 52

What is one dose treatment for Trichomonas Metronidazole 2 grams 3/02/2009 conceptclues.blogspot.com 53

What are the 3 cephalosporins & doses used as one dose tx for gonorrhea Ceftriaxone = 250mg IM Cefixime = 400 mg PO Cefoxitin = 400 mg PO 3/02/2009 conceptclues.blogspot.com 54

What are the 4 enzymes needed to break down glycogen 3/02/2009 conceptclues.blogspot.com 55

What are the 2 enzymes needed for make glycogen 3/02/2009 conceptclues.blogspot.com 56

What are the branching enzymes 3/02/2009 conceptclues.blogspot.com 57

3/02/2009 conceptclues.blogspot.com 58 What are the rate limiting enzyme in the break down of glycogen phosphorylase

what values do u see in obstructive pulmonary disease pO2 = normal PCO2 = normal or increased pH = decreased 3/02/2009 conceptclues.blogspot.com 59

What values do u see in restrictive pulmonary disease pO2 = Decreased PCO2 = Decreased pH = Increased 3/02/2009 conceptclues.blogspot.com 60

What type of acidosis do u see with obstructive pulmonary disease Respiratory Acidosis 3/02/2009 conceptclues.blogspot.com 61

What are the lysosomal storage disease & what’s its deficiency 3/02/2009 conceptclues.blogspot.com 62

What diseases are a/w HLA-B27 3/02/2009 conceptclues.blogspot.com 63

What HLA is Psoriasis w/ Rhematoid Arthritis associated with HLA-13 3/02/2009 conceptclues.blogspot.com 64

What are the glycogen storage diseases & deficiency 3/02/2009 conceptclues.blogspot.com 65

What are the 6 places of TCA cycle where amino acids fee in/out 3/02/2009 conceptclues.blogspot.com 66

What are the 4 steps of B-Oxidation 3/02/2009 conceptclues.blogspot.com 67

What are the blood gases in neuromuscular disease Same as the restrictive blood gases pO2 = decreased pCO2 = decreased PCWP = decreased b/c its pressure problem Respiratory Rate = increased pH = increased Seizure = increased 3/02/2009 conceptclues.blogspot.com 68

What are the 5 hormones produced by small cell (oat cell) lung cancer 3/02/2009 conceptclues.blogspot.com 69

What autoimmune disease has the following autoimmune antibodies 3/02/2009 conceptclues.blogspot.com 70

Autoimmune antibody for drug induced SLE Anti-Histone 3/02/2009 conceptclues.blogspot.com 71