3 Breast Cancer

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The breast is a mass of glandular, fatty, and fibrous tissues positioned over the pectoral muscles of the chest wall and attached to the chest wall by fibrous strands called Cooper’s ligaments. A layer of fatty tissue surrounds the breast glands and extends throughout the breast. The glandular tissues of the breast house the lobules (milk producing glands at the ends of the lobes) and the ducts (milk passages).

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a complex cyst with thick wall, mural nodule and echogenic fluid contents

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The photomicrographs show malignant papillary epithelial structures projecting into the cyst cavity. Minimal areas of superficial invasion were also present.

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Breast Cancer Keith Bradley, MD Director National Alliance of Research Associates Programs (NARAP)

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Breast Cancer 2nd most common form of cancer in women 1,300 cases of male breast cancer are dx’d, and 400 men will die from this disease 1/9 women will develop breast cancer in her lifetime incidence rises sharply after age 40 about 77 percent of invasive breast cancers occur in women over age 50

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Breast Cancer Prevention maintain a healthy weight or lose excess weight maintain a diet low in fat exercise regularly avoid alcohol and smoking

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Breast Cancer Risk Factors personal or family history of breast cancer nulliparous or having a first child after age 30 radiation therapy to the chest or upper body previous breast biopsies and benign breast disease atypical hyperplasia = cells abnormal and  number lobular carcinoma in situ = abnormal cells in lining of milk-producing tissue

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Breast Cancer Risk Factors Majority of breast cancer cases occur in women with no identifiable risk factors

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Breast Cancer Screening Self breast exam monthly Clinical breast exam yearly after age 20 Mammogram biennially from age 50-74

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Breast Cancer Early Detection screening mammogram (low-dose x-ray) to detect breast cancer at its earliest stage up to two years before it is large enough to be felt by a medical professional recent national survey, 63 percent of women in the U.S. between 40-64 had a mammogram within the past year

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Breast Cancer Mammogram

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Find a mass  ?

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Find a mass  Biopsy stereotactic core needle, US-guided biopsy office procedure > 80% biopsied breast abnormalities = benign Of those = malignant, 63% = early, “localized” stage five-year survival after treatment = 97% 6% diagnosed at an advanced or metastatic stage five-year survival rate after treatment = 23%

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Quiz complete the Breast Cancer quiz found on the www.theNARAP.org website save as YourLastName,YourFirstName-BreastCancer send to your Chief RA for Recruiting

Summary: This presentation is part of pre-orientation for new Research Associates. Please be advised that this includes medically graphic material.

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